Stability of human recombinant AIMP1/P43 protein in complex with tRNA
نویسندگان
چکیده
منابع مشابه
Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.
Aminoacylation of tRNA is the first step of protein synthesis. Here, we report the co-crystal structure of human tryptophanyl-tRNA synthetase and tRNATrp. This enzyme is reported to interact directly with elongation factor 1alpha, which carries charged tRNA to the ribosome. Crystals were generated from a 50/50% mixture of charged and uncharged tRNATrp. These crystals captured two conformations ...
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It is believed that the critical step in the pathogenesis of transmissible spongiform encephalopathies is a transition of prion protein (PrP) from an alpha-helical conformation, PrP(C), to a beta-sheet-rich form, PrP(Sc). Native prion protein contains a single disulfide bond linking Cys residues at positions 179 and 214. To elucidate the role of this bridge in the stability and folding of the p...
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ژورنال
عنوان ژورنال: Bulletin of Taras Shevchenko National University of Kyiv. Series: Problems of Physiological Functions Regulation
سال: 2016
ISSN: 1728-2624,2616-6410
DOI: 10.17721/2616_6410.2016.21.49-52